Regulation of the interleukin-3 (IL-3) receptor by IL-3 in the fetal liver-derived FL5.12 cell line

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Regulation of the interleukin-3 (IL-3) receptor by IL-3 in the fetal liver-derived FL5.12 cell line.

To determine the effects of a cytokine on cognate receptor expression in normal and neoplastic cells, the interleukin-3 receptor (IL-3R) complex was examined in the parental IL-3-dependent line FL5.12, which was isolated from fetal liver, and in autocrine- and v-abl-transformed derivative lines. IL-3 decreased the amount of the IL-3R alpha and beta chains detected on the cell surface of the par...

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ژورنال

عنوان ژورنال: Blood

سال: 1994

ISSN: 0006-4971,1528-0020

DOI: 10.1182/blood.v83.9.2459.2459